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KMID : 1007520220310101289
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Food Science and Biotechnology
2022 Volume.31 No. 10 p.1289 ~ p.1297
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Gryllus bimaculatus extract ameliorates high-fat diet-induced hyperglycemia and hyperlipidemia by inhibiting hepatic lipogenesis through AMPK activation
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Kim Kyong
Park Eun-Young
Baek Dong-Jae
Oh Yoon-Sin
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Abstract
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Insect-based food is increasingly used and is a sustainable protein source provided by eco-friendly breeding respecting the animal welfare. The cricket Gryllus bimaculatus is an approved edible insect. In this paper, the effects of G. bimaculatus extracts (AE-GBE) on hepatic insulin resistance and the underlying mechanisms were investigated in high fat diet (HFD)-fed C57BL/6J mice. Mice were fed HFD for 6 weeks and some were concomitantly given AE-GBE orally (100 mg/kg/day). AE-GBE significantly improved glucose tolerance and insulin sensitivity by attenuating hepatic lipid accumulation measured by the reduced serum and hepatic lipid contents. Moreover, AE-GBE significantly downregulated the expression of hepatic lipogenesis-related genes and activated the AMPK signaling pathway. Therefore, AE-GBE might improve fatty liver and glucose metabolism disorders as well as insulin resistance by inhibiting the expression of proteins involved in hepatic fatty acid synthesis through AMPK activation.
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KEYWORD
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AMP-activated protein kinase, Gryllus bimaculatus, Hepatic insulin resistance, Lipogenesis, Nonalcoholic fatty liver disease
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